{"edges":[{"object_category":"biolink:Cell","object_id":"CL:0000037","predicate":"biolink:expressed_in","subject_category":"biolink:Gene","subject_id":"NCBIGene:216"},{"object_category":"biolink:Gene","object_id":"NCBIGene:11036","predicate":"biolink:regulates","subject_category":"biolink:Gene","subject_id":"NCBIGene:1457"},{"object_category":"biolink:Gene","object_id":"NCBIGene:653604","predicate":"biolink:regulates","subject_category":"biolink:MacromolecularComplex","subject_id":"SIGNOR:SIGNOR-C409"},{"object_category":"biolink:PhenotypicFeature","object_id":"SIGNOR:SIGNOR-PH122","predicate":"biolink:regulates","subject_category":"biolink:MacromolecularComplex","subject_id":"SIGNOR:SIGNOR-C379"},{"object_category":"biolink:Gene","object_id":"NCBIGene:100","predicate":"biolink:regulates","subject_category":"biolink:ChemicalEntity","subject_id":"PUBCHEM:CID:439693"},{"object_category":"biolink:Gene","object_id":"NCBIGene:114907","predicate":"biolink:regulates","subject_category":"biolink:Protein","subject_id":"UNIPROT:A8MYZ6"},{"object_category":"biolink:MacromolecularComplex","object_id":"SIGNOR:SIGNOR-C165","predicate":"biolink:regulates","subject_category":"biolink:Gene","subject_id":"NCBIGene:7448"},{"object_category":"biolink:Gene","object_id":"NCBIGene:6755","predicate":"biolink:regulates","subject_category":"biolink:SmallMolecule","subject_id":"ChEBI:CHEBI:64628"},{"object_category":"biolink:SmallMolecule","object_id":"ChEBI:CHEBI:17202","predicate":"biolink:regulates","subject_category":"biolink:SmallMolecule","subject_id":"ChEBI:CHEBI:58467"},{"object_category":"biolink:ProteinFamily","object_id":"SIGNOR:SIGNOR-PF17","predicate":"biolink:regulates","subject_category":"biolink:SmallMolecule","subject_id":"ChEBI:CHEBI:17489"},{"object_category":"biolink:Gene","object_id":"NCBIGene:84676","predicate":"biolink:regulates","subject_category":"biolink:ProteinFamily","subject_id":"SIGNOR:SIGNOR-PF27"},{"object_category":"biolink:Gene","object_id":"NCBIGene:90993","predicate":"biolink:regulates","subject_category":"biolink:EnvironmentalProcess","subject_id":"SIGNOR:SIGNOR-ST22"},{"object_category":"biolink:PhenotypicFeature","object_id":"SIGNOR:SIGNOR-PH62","predicate":"biolink:regulates","subject_category":"biolink:Gene","subject_id":"NCBIGene:338"},{"object_category":"biolink:MacromolecularComplex","object_id":"SIGNOR:SIGNOR-C3","predicate":"biolink:regulates","subject_category":"biolink:MacromolecularComplex","subject_id":"SIGNOR:SIGNOR-C15"},{"object_category":"biolink:Protein","object_id":"UNIPROT:E9PAV3","predicate":"biolink:regulates","subject_category":"biolink:Gene","subject_id":"NCBIGene:2932"},{"object_category":"biolink:ProteinFamily","object_id":"SIGNOR:SIGNOR-PF27","predicate":"biolink:regulates","subject_category":"biolink:ProteinFamily","subject_id":"SIGNOR:SIGNOR-PF24"},{"object_category":"biolink:MacromolecularComplex","object_id":"SIGNOR:SIGNOR-C174","predicate":"biolink:regulates","subject_category":"biolink:ProteinFamily","subject_id":"SIGNOR:SIGNOR-PF48"},{"object_category":"biolink:MacromolecularComplex","object_id":"SIGNOR:SIGNOR-C3","predicate":"biolink:regulates","subject_category":"biolink:ChemicalEntity","subject_id":"ChEBI:CHEBI:9168"},{"object_category":"biolink:MacromolecularComplex","object_id":"SIGNOR:SIGNOR-C155","predicate":"biolink:regulates","subject_category":"biolink:SmallMolecule","subject_id":"ChEBI:CHEBI:29108"},{"object_category":"biolink:Protein","object_id":"UNIPROT:P23966","predicate":"biolink:regulates","subject_category":"biolink:MacromolecularComplex","subject_id":"SIGNOR:SIGNOR-C497"},{"object_category":"biolink:ProteinFamily","object_id":"SIGNOR:SIGNOR-PF24","predicate":"biolink:regulates","subject_category":"biolink:MacromolecularComplex","subject_id":"SIGNOR:SIGNOR-C2"},{"object_category":"biolink:MacromolecularComplex","object_id":"SIGNOR:SIGNOR-C518","predicate":"biolink:in_complex_with","subject_category":"biolink:ProteinFamily","subject_id":"SIGNOR:SIGNOR-PF89"},{"object_category":"biolink:MacromolecularComplex","object_id":"SIGNOR:SIGNOR-C429","predicate":"biolink:in_complex_with","subject_category":"biolink:MacromolecularComplex","subject_id":"SIGNOR:SIGNOR-C428"},{"object_category":"biolink:PhenotypicFeature","object_id":"SIGNOR:SIGNOR-PH4","predicate":"biolink:regulates","subject_category":"biolink:Protein","subject_id":"SIGNOR:SIGNOR-FP2"},{"object_category":"biolink:MacromolecularComplex","object_id":"SIGNOR:SIGNOR-C452","predicate":"biolink:in_complex_with","subject_category":"biolink:SmallMolecule","subject_id":"ChEBI:CHEBI:15996"},{"object_category":"biolink:ProteinFamily","object_id":"SIGNOR:SIGNOR-PF81","predicate":"biolink:regulates","subject_category":"biolink:ChemicalEntity","subject_id":"ChEBI:CHEBI:6801"},{"object_category":"biolink:Gene","object_id":"NCBIGene:5468","predicate":"biolink:regulates","subject_category":"biolink:MicroRNA","subject_id":"RNAcentral:URS000039E12D_9606"},{"object_category":"biolink:MacromolecularComplex","object_id":"SIGNOR:SIGNOR-C463","predicate":"biolink:in_complex_with","subject_category":"biolink:ChemicalEntity","subject_id":"ChEBI:CHEBI:57692"},{"object_category":"biolink:PhenotypicFeature","object_id":"SIGNOR:SIGNOR-PH170","predicate":"biolink:regulates","subject_category":"biolink:ProteinFamily","subject_id":"SIGNOR:SIGNOR-PF66"},{"object_category":"biolink:PhenotypicFeature","object_id":"SIGNOR:SIGNOR-PH158","predicate":"biolink:regulates","subject_category":"biolink:SmallMolecule","subject_id":"ChEBI:CHEBI:29108"},{"object_category":"biolink:Gene","object_id":"NCBIGene:931","predicate":"biolink:regulates","subject_category":"biolink:Drug","subject_id":"DRUGBANK:DB06650"},{"object_category":"biolink:MacromolecularComplex","object_id":"SIGNOR:SIGNOR-C154","predicate":"biolink:regulates","subject_category":"biolink:Protein","subject_id":"UNIPROT:P59595"},{"object_category":"biolink:MacromolecularComplex","object_id":"SIGNOR:SIGNOR-C434","predicate":"biolink:in_complex_with","subject_category":"biolink:Protein","subject_id":"UNIPROT:P0DOX8"},{"object_category":"biolink:Gene","object_id":"NCBIGene:4233","predicate":"biolink:regulates","subject_category":"biolink:Noncoding_RNAProduct","subject_id":"RNAcentral:URS000075C808_9606"},{"object_category":"biolink:ProteinFamily","object_id":"SIGNOR:SIGNOR-PF56","predicate":"biolink:regulates","subject_category":"biolink:Protein","subject_id":"UNIPROT:Q9BYB0"},{"object_category":"biolink:Protein","object_id":"SIGNOR:SIGNOR-FP6","predicate":"biolink:regulates","subject_category":"biolink:ChemicalEntity","subject_id":"ChEBI:CHEBI:39112"},{"object_category":"biolink:Protein","object_id":"UNIPROT:A8MYZ6","predicate":"biolink:regulates","subject_category":"biolink:ProteinFamily","subject_id":"SIGNOR:SIGNOR-PF24"},{"object_category":"biolink:SmallMolecule","object_id":"ChEBI:CHEBI:17759","predicate":"biolink:regulates","subject_category":"biolink:EnvironmentalProcess","subject_id":"SIGNOR:SIGNOR-ST17"},{"object_category":"biolink:Protein","object_id":"UNIPROT:P01189-PRO_0000024969","predicate":"biolink:regulates","subject_category":"biolink:SmallMolecule","subject_id":"ChEBI:CHEBI:16469"},{"object_category":"biolink:PhenotypicFeature","object_id":"SIGNOR:SIGNOR-PH37","predicate":"biolink:regulates","subject_category":"biolink:MicroRNA","subject_id":"RNAcentral:URS000037EC34_9606"},{"object_category":"biolink:Protein","object_id":"SIGNOR:SIGNOR-FP4","predicate":"biolink:regulates","subject_category":"biolink:MicroRNA","subject_id":"RNAcentral:URS000075AE07_9606"},{"object_category":"biolink:Drug","object_id":"CHEBI:133021","predicate":"biolink:associated_with_sensitivity_to","subject_category":"biolink:Gene","subject_id":"NCBIGene:596"},{"object_category":"biolink:Drug","object_id":"CHEBI:133021","predicate":"biolink:associated_with_resistance_to","subject_category":"biolink:Gene","subject_id":"NCBIGene:712"},{"object_category":"biolink:Disease","object_id":"MONDO:0018874","predicate":"biolink:GeneToDiseaseOrPhenotypicFeatureAssociation","subject_category":"biolink:Gene","subject_id":"NCBIGene:1788"},{"object_category":"biolink:Disease","object_id":"MONDO:0018874","predicate":"biolink:treats","subject_category":"biolink:Drug","subject_id":"CHEBI:2038"},{"object_category":"biolink:Disease","object_id":"MONDO:0000875","predicate":"biolink:subclass_of","subject_category":"biolink:Disease","subject_id":"MONDO:0018874"}]}